Acute disseminated encephalomyelitis: Treatment guidelines
نویسندگان
چکیده
Acute disseminated encephalomyelitis (ADEM) is a monophasic, postinfectious or postvaccineal acute infl ammatory demyelinating disorder of central nervous system (CNS).[1,2] The pathophysiology involves transient autoimmune response directed at myelin or other self-antigens, possibly by molecular mimicry or by nonspecifi c activation of autoreactive T-cell clones.[3] Histologically, ADEM is characterized by perivenous demyelination and infi ltration of vessel wall and perivascular spaces by lymphocytes, plasma cells, and monocytes.[4]
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